心肌細(xì)胞是機(jī)體*具有活力的細(xì)胞。它們是高度分化的高氧含量的細(xì)胞，擁有大量的線粒體。心肌細(xì)胞占有心臟重量的75%，但僅為心臟細(xì)胞數(shù)量的1/3。高度分化的心肌細(xì)胞幾乎沒有增殖能力，它們在a-腎上腺素的刺激下通過Ras/MEK途徑發(fā)生肥大生長。所有的心肌細(xì)胞都能自律性的將膜去極化和復(fù)極化。所有的心肌細(xì)胞收縮都是肌源性的，不受神經(jīng)系統(tǒng)刺激。心肌細(xì)胞具有復(fù)雜的信號網(wǎng)絡(luò)，從而調(diào)節(jié)其在心臟節(jié)律性的泵出功能中的作用。心力衰竭時，心肌細(xì)胞的肥大和凋亡導(dǎo)致心肌收縮功能的下降。更好地了解心臟信號系統(tǒng)有助于揭示心肌細(xì)胞死亡的細(xì)胞機(jī)制。
Sciencell研究實(shí)驗(yàn)室的HCM是從人心臟分離得到的，原代凍存，冰凍運(yùn)輸。每管細(xì)胞密度超過1×10^6/ml。細(xì)胞特性經(jīng)肌球蛋白（myosin）免疫熒光鑒定。本細(xì)胞經(jīng)檢測不含HIV-1、HBV、HCV、支原體、細(xì)菌、酵母菌和真菌。如采用ScienCell?實(shí)驗(yàn)室提供的培養(yǎng)條件，可保證此細(xì)胞繼續(xù)的培養(yǎng)。HCM因?yàn)椴荒茉鲋常什荒軌驍U(kuò)大或長期培養(yǎng)。?
推薦培養(yǎng)基：心肌細(xì)胞培養(yǎng)基 (CMM, Cat. #6201)
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貨號
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6200
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產(chǎn)地
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美國
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縮寫
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HCM
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規(guī)格
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1 x 10^6 /1ml
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用途
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科研
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儲存
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液氮
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運(yùn)輸
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干冰
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關(guān)鍵字
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人心肌細(xì)胞 HCM 人心肌細(xì)胞 HCM 人心肌細(xì)胞 HCM 人心肌細(xì)胞 HCM 人心肌細(xì)胞 HCM 人心肌細(xì)胞 HCM 人心肌細(xì)胞 HCM
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公司簡介
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合肥星肽生物科技有限公司作為專業(yè)的ScienCell中國代理商，專業(yè)經(jīng)營實(shí)驗(yàn)室科研用原代細(xì)胞、原代細(xì)胞專用培養(yǎng)基、原代細(xì)胞無血清培養(yǎng)基、干細(xì)胞、干細(xì)胞培養(yǎng)基、干細(xì)胞無血清培養(yǎng)基的研究和開發(fā)。合肥星肽生物科技有限公司始終致力于為客戶提供可靠的研究材料以及方便快捷的服務(wù)，對購買項(xiàng)目的前期資料提供,中期合同保證,后期貨物跟蹤到 *終售后的確保項(xiàng)目準(zhǔn)確到位，都有相關(guān)專業(yè)人士進(jìn)行維護(hù),確保您在合肥合肥星肽生物科技有限公司公司獲得*上等服務(wù)！
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聯(lián)系方式
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何經(jīng)理，合肥星肽生物科技有限公司，Tel：0551-63802898 400-8702-898，
E-mail：info@qingbio.com http://m.huangyuansheng.cn QQ:514713116
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1.) Wang E, Sun S, Qiao B, Duan W, Huang G, An Y, Xu S, Zheng Y, Su Z, Gu X, Jin L, Wang H. (2013) "Identification of functional mutations in GATA4 in patients with congenital heart disease." PLoS One. 8: e62138.
2.) Bauwens CL, Song H, Thavandiran N, Ungrin M, Mass? S, Nanthakumar K, Seguin C, Zandstra PW. (2011) "Geometric Control of Cardiomyogenic Induction in Human Pluripotent Stem Cells." Tissue Eng Part A. 17: 1901-9.
3.) Mukhopadhyay P, Rajesh M, B?tkai S, Patel V, Kashiwaya Y, Liaudet L, Evgenov OV, Mackie K, Hask? G, Pacher P. (2010) "CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes." Cardiovasc Res. 85: 773-84.
4.) Voigt A, Trimpert C, Bartel K, Egerer K, Kuckelkorn U, Feist E, Gericke C, Klingel K, Kandolf R, Felix SB, Baumann G, Kloetzel PM, Stangl K, Staudt A. (2010) "Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathy." Basic Res Cardiol. 105: 557-67.
5.) Yeh YC, Wei HJ, Lee WY, Yu CL, Chang Y, Hsu LW, Chung MF, Tsai MS, Hwang SM, Sung HW. (2010) "Cellular cardiomyoplasty with human amniotic fluid stem cells: in vitro and in vivo studies." Tissue Eng Part A. 16: 1925-36.
6.) Hussein S, Michael P, Brabant D, Omri A, Narain R, Passi K, Ramana CV, Parrillo JE, Kumar A, Parissenti A, Kumar A. (2009) "Characterization of human septic sera induced gene expression modulation in human myocytes." Int J Clin Exp Med. 2: 131-48.
7.) Kim KS, Chapman NM, Tracy S. (2008) "Replication of coxsackievirus B3 in primary cell cultures generates novel viral genome deletions." J Virol. 82: 2033-7.
8.) Pan CH, Wen CH, Lin CS. (2008) "Interplay of angiotensin II and angiotensin(1-7) in the regulation of matrix metalloproteinases of human cardiocytes." Exp Physiol. 93: 599-612.
9.) Jiang Y, Reynolds C, Xiao C, Feng W, Zhou Z, Rodriguez W, Tyagi SC, Eaton JW, Saari JT, Kang YJ. (2007) "Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice." J Exp Med. 204: 657-66.
10.) Li SY, Sigmon VK, Babcock SA, Ren J. (2007) "Advanced glycation endproduct induces ROS accumulation, apoptosis, MAP kinase activation and nuclear O-GlcNAcylation in human cardiac myocytes." Life Sci. 80: 1051-6.
11.) Ng ES, Cheng ZJ, Ellis A, Ding H, Jiang Y, Li Y, Hollenberg MD, Triggle CR. (2007) "Nitrosothiol stores in vascular tissue: Modulation by ultraviolet light, acetylcholine and ionomycin." Eur J Pharmacol. 560: 183-92.
12.) Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R, Bacus SS. (2007) "Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells." Proc Natl Acad Sci USA. 104: 10607-12.
13.) Li SY, Li Q, Shen JJ, Dong F, Sigmon VK, Liu Y, Ren J. (2006) "Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling." J Mol Cell Cardiol. 40: 283-94.
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